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WebMacrophage migration inhibitory factor (MIF) has recently emerged as an important cytokine in the pathophysiology of sepsis, and high levels of MIF in patients with septic shock and ARDS correlate with poor outcome.37,38 MIF possesses a number of biological activities generally directed toward a proinflammatory phenotype, including skewing of … WebMacrophage migration inhibitory factor (MIF) is a pleiotropic proinflammatory cytokine that has been implicated as playing a causative role in many disease states, including sepsis, pneumonia, diabetes, rheumatoid arthritis, inflammatory bowel disease, psoriasis and cancer. To inhibit the enzymatic and biologic activities of MIF, we and others ... the government green book
Discovery of novel MIF inhibitors that attenuate microglial
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