Human muc1 peptide
Web27 Oct 2005 · MUC1 mucins are highly glycosylated type I glycoproteins expressed by various normal and malignant epithelial cells such as breast, kidney and ovarian cancers and hematologic malignancies including acute myelogenous leukemia (AML), multiple myeloma and some B-cell lymphoma [ 7 – 9 ]. Web26 Jul 2016 · Different types of MUC1-peptide vaccines have been synthesized chemically to produce effective anti-MUC1 immune responses. It has been found that using MUC1 alone does not produce strong immune responses, which necessitates the use of adjuvant and/or different T and B cell epitopes.
Human muc1 peptide
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WebHuman MUC1 is composed of a cytoplasmic signaling peptide, a transmembrane domain, and an ectodomain composed of a variable number tandem repeats of twenty amino acids. Each repeat contains five potential O -glycosylation sites. The glycosylation pattern depends on the tissue of origin and the physiological state of the tissue ( 1, 3 ). Web8 Apr 2024 · In normal human tissues, membrane-bound MUC1 is known to be expressed at the apical surface of glandular or luminal epithelial cells, such as the lung, mammary gland, stomach and salivary glands 5 ...
Web1 Jul 2024 · The transmembrane mucin TR reporters were designed by fusion of human MUC1 signal peptide (amino acids 1–-62, Uniprot P15921) with 6xHis, Flag-tag, EGFP, multiple cloning site, and the membrane ... Web21 May 2024 · The MUC1 glycoprotein was first identified as the antigen found in extracts of the human milk fat globule membranes, or in extracts of cancer cells, which induced a …
Web14 Nov 2012 · The most frequent epitopes recognised by human MUC1 antibodies include the peptides RPAPGS, PPAHGVT and PDTRP within the VNTR – . Antigenic epitopes have also been identified in MUC1 in regions outside of the core VNTR repeat region . One such epitope spans amino acids 90–110 in the extracellular domain . Sequence analysis … WebSeveral MUC1 peptide vaccines, differing in vectors, carrier proteins and adjuvants, have been tested in phase I clinical trials. They are capable of inducing predominantly humoral …
Web1 Jul 1999 · The key to eliciting potent immunity to tumor MUC1 may be in generating MUC1-specific T-helper cell responses, which, to date, have not been reported in cancer patients. We have recently demonstrated that a synthetic vaccine representing five copies of the MUC1 tandem repeat peptide can be used to prime MUC1-specific human CD4+ T cells …
Webtion (1, 2). MUC1 is a heavily glycosylated type 1 transmembrane mucin that is expressed on the apical surface of glandular epi-thelial cells at low levels and at very high levels … do you pay for covid testsWeb24 Sep 2024 · Abstract. Because of our interest in developing new hybrid peptide radioconjugates with suitable biochemical properties for multiple-receptors targeting properties that are overexpressed on many human cancers especially ovarian cancer, we have synthesized 68 Ga-NODAGA-MUC1 and 68 Ga-NODAGA-MUC1-FA hybrid … emergency services near marysvilleWeb18 Mar 2024 · The cell-binding activity of the MUC1-[18 F] SFB and MUC1-FA-[18 F] SFB hybrid peptide conjugates were measured on the human MCF7 breast cancer cell line (ATCC, Rockville, MD). MCF7 cell line was grown in RPMI-1640 culture media with 10% fetal bovine serum (FBS) in tissue culture flasks. 24 h prior to conducting the cell-binding … do you pay for college applicationsWebAmong the human mucins, MUC1 is unique in its cell-surface transmembrane expression and its apparent signal-transduction functions. The high expression of MUC1 on many human cancers makes it an attractive target for immunotherapy. Immunization of human cancer patients with MUC1 peptides has resulted in the generation of both anti-MUC1 … do you pay for dentist check upsWebMUC1 Background Information Mucin 1, cell surface-associated (MUC1) or polymorphic epithelial mucin (PEM) is a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. do you pay for dstv rewardsWeb1 Mar 1998 · Mice immunized with mannan-MUC1-peptides make cytotoxic T lymphocytes (CTLs) and are protected from MUC1 + tumors. We show that the same specific anti … do you pay for facebook business pageWebMucin 1 (MUC1) is a transmembrane mucin glycoprotein expressed on the surface of almost all epithelial cells. Aberrantly glycosylated MUC1 is associated with cellular … emergency services near sebastopol